她能逃过一切，唯独逃不过他。曾是逃亡司机的她早已脱离危险日子，却为了拯救那个老是闯祸的前男友，再度飙命出击。

宾夕法尼亚州南部的布鲁斯特市，资深的火车机师弗兰克·巴恩斯（丹泽尔·华盛顿DenzelWashington饰）即将提前退休，作为拥有丰富阅历和经验的老员工，他和伙伴们虽然对公司出于成本雇用相对便宜却没有经验的新员工不满，却也无可奈何。这天早晨，弗兰克迎来了新的搭档，年轻气盛的领航员威尔·科尔森（克里斯·佩恩ChrisPine饰），新老交替正式开始。与此同时，位于北部的富勒站出现状况，满载危险化学品的777号列车在无人驾驶的情况下径自开走，如野兽般咆哮着冲向人口密集的城镇。危险随时降临，弗兰克和威尔即将度过难忘的一天……本片根据2001年美国俄亥俄州的一个真实事件改编。

　　World renowned journalist Sara Ogden is traversing the world in pursuit of carriers of a fatally dangerous "Stamp of Cain" in order to prevent seemingly unrelated events such as mass murders, turmoil, revolutions and chaos. She doesn't even suspect how close she is to the edge of the abyss, when in her search she ends up in Belarus to meet face to face with the one, whom she has been searching for her entire life.